Windows or Linux?

If Windows, consider moving to Linux. Windows is not an ideal operating system if you have many users & labs.

Is DB and App on different servers?

If not, consider moving it.

Check Tomcat memory allocation

Tomcat should be assigned 2GB memory to run optimally.  Open the 'setenv.sh' file in the '<tomcat directory>/bin' directory, and check if -Xmx2048m is  present in the below line.

export JAVA_OPTS="-Dfile.encoding=UTF-8 -Xms128m -Xmx2048m -XX:PermSize=64m -XX:MaxPermSize=512m"

Check DB memory allocation

Please refer to "Increase memory for better query performance" in MySQL prerequisites page. If Oracle, consult your DBA.

Check CPU and memory utilization.

• Open Task Manager (Windows) or top command (Linux).
• Check if any process entirely consumes CPU or memory. If some process is hogging all the resources, identify the process, and check what is going on with it.
• Repeat this on both app and DB server.

Check database transactions

• Login into the database.
• Run the following command for MySQL: 

show full processlist;

• It will display current running transactions in the database.
• Check if any of the processes are long-running or hogging all the DB resources.
• If yes, identify the query and check if it was run by OpenSpecimen application.